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A cardiologist warns: these 5 medications increase the risk of heart attack and stroke in older people

That headline needs some context. There isn’t a universal list of five medications that older people should avoid because they cause heart attacks or strokes. The cardiovascular risk depends on the medication, dose, duration, existing heart disease, blood pressure, kidney function, and interactions with other drugs.

Some medication groups that deserve particular caution include:

  1. Non-aspirin NSAIDs — such as ibuprofen, naproxen, diclofenac, and celecoxib. They can increase the risk of heart attack and stroke, with risk potentially appearing early and increasing with higher doses or longer use. Mayo Clinic+1

  2. Decongestants — pseudoephedrine and phenylephrine can constrict blood vessels and raise blood pressure, which is particularly concerning for people with cardiovascular disease or uncontrolled hypertension. www.heart.org

  3. Some antipsychotic medicines — in older adults with dementia, antipsychotics are associated with increased risks of stroke and death. Mayo Clinic

  4. Certain medicines that cause significant blood-pressure drops — multiple drugs can contribute to orthostatic hypotension, increasing dizziness and fall risk; the combination of medicines is often important. U.S. Food and Drug Administration+1

  5. Medication combinations that increase cardiovascular or bleeding risk — for example, combining NSAIDs with anticoagulants or antiplatelet medicines can substantially increase complications. Merck Manuals

One important warning

Don’t stop a prescribed heart or blood-pressure medication on your own. Many medicines that have potential risks are also highly beneficial when appropriately prescribed. The FDA specifically recommends discussing medication problems with a healthcare professional rather than stopping treatment independently. U.S. Food and Drug Administration

If you give me the five medications mentioned in the article/video, I can explain each one—what the actual heart/stroke evidence says, who is most at risk, and what safer alternatives may be available .

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